I’d say focus on a cause, not on on particular issue. For example, FAN is about reclaiming the word “neighborhood” for the voices of inclusion. Many individual issues fall under the umbrella of this cause. Each person decides in their own mind which issues are key for them.
That said, at any particular time, an individual issue can galvanize people, provide urgency, and serve as a powerful example of the more general cause you are advocating.